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Gail Rae Hudson

I'm pleased that you highlighted, in this article, the growing concern among researchers that genetic research isn't as definitive as we've wanted to think. I, too, recently read an article that talked about the same situation. Genetic research, we're beginning to understand, isn't as simple as, say, a drone being programmed to hit a specified target. We're not even sure, at this point, what constitutes a target.
Good advice, at this point, that it's probably premature to "put one's life in order" when genetic testing, in its current state, reveals a 19% or 37% probability of disease.

Gerta Farber

I am an 83 year old woman and a member of a genetic-Alzheimer's family. In
my lifetime I am aware of nine family members who have been victims of AD,
the last four in my generation.

In the 20 years since an autopsy specified my mother's AD, dementia-
research has mostly consisted of the very limited success of pharmaceutical
trials. This tunnel-vision has resulted in my familiy's continuing tragedies.

Currently, researchers are reportedly seeking new ways to identify
pre-symptomatic members of such genetic families. They are searching for
methods to identify those at high-risk, who are not yet experiencing
cognitive impairments, so as to test "preventive" medications or life-styles.

This testing is awaiting procedural determination, but there is no need of
evaluating pre-clinical subjects, when critical diagnostic testing and histories
already exist for those who have been diagnosed, or will be diagnosed, with

There could be an unlimited number of study participants; families like mine
that are desperate to find answers. Incredibly, current tests are now
uncovering conditions that may be causing or aggravating cognition, without
the further knowledge of probable linkage to COMMON causes.

True causes and preventives of dementia would undeniably emerge in the
comparative histories of millions of patients. A "National Registry" using
instant computerized technology can provide the imperative missing evidence,
and a vital public-reference for genetic links and statistics.

The factors rightly being researched are "nutritional, pharmaceutical, toxic
and environmental, genetic, social/economic, behavioral, medical (such as
other neurodegenerative diseases and pathologies). The lack of volunteers
that has been noted by the researchers as their greatest obstacle, is easily
overcome if dementia evaluations become comparable statistics.

A diagnostic framework and guiding terminology can be created, to organize
categories, stages, and the ongoing global study of brain disease, but can
the historical impediments of our political and pharmaceutical limitations
finally be overcome?

Gerta Farber
2951 Derby St. #113
Berkeley CA 94705
510 841-2050

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