The draft consensus statement is out and underscores the uncertainty behind the diagnosis of Alzheimer's and theories on prevention of Alzheimer's and,more generally, any cognitive decline. Some excerpts from the Conclusions portion of the draft statement:
- There is an absence of highly reliable consensus-based diagnostic criteria for both cognitive decline and Alzheimer's disease, and the available criteria have not been uniformly applied
- Firm conclusions cannot be drawn about the association of modifiable risk factors with cognitive decline or Alzheimer's disease
- There is insufficient evidence to support the use of pharmaceutical agents or dietary supplements to prevent cognitive decline or Alzheimer's disease
- Large scale population-based studies and RCTs are critically needed...
The level of uncertainty expressed seems appropriate to me. The level of complexity of definitions and risk factors makes me wonder how successful any scientific studies can be.
The panel is taking public comment this morning, then will issue a final statement at 2 pm eastern today.