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January 17, 2007


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Gail Rae Hudson

I'm glad you wrote about this. Although our paper didn't have a headline, I noticed the story, which was considered exciting enough to put on page one. My interest, of course, was compounded by the fact that my mother would probably be considered to have "late onset" dementia, as did my grandmother.

As I was reading the last half of your post, Mona, and considering the mention of the huge amount of work still to be done regarding controlling (or eliminating) dementia in the elderly (and other populations), I suddenly realized that the real challenge is understanding why the body, why any being, seems to be firmly embraced in a "life eventually = breakdown and death" cycle. My guess, despite the occasional optimistic pronouncement by the few and vocal techno-geniuses who believe we will eventually eradicate death, is that we may never eradicate death but, wouldn't it be nice to arrive at Death's door with one's wits about them? Since death=breakdown, it's possible that the impetus to life will find different ways to break us down as we eliminate the one's with which we're familiar. But, wrestling with breakdown is probably more productive than trying to wrestle with death. Death doesn't seem to care, or be put off, by the many rounds we've managed to add, in the last century, to our match with it.

Anyway, thanks again, Mona. I wondered, when I read the very short article in yesterday's paper, what this might mean. As usual, you've covered it with outstanding perceptiveness.

Mary Emma Allen

Thank you for writing about this topic in laymen's terms. I've mentioned your post on Alzheimer's Notes.


I certainly enjoy reading your posts and be reminded that at the very least there are people out there doing Alzheimer's research. Sometimes the hardest thing about having my mother disappear with this disease is worrying that the same thing is going to happen to me. It is hopeful to know that due to research, maybe something about it'll be different....of course, I'm now at the point that I don't have space to worry about anything other than her, but that's a different story.


I am a student currently reviewing this sepecific article on SORL1. I must say, your blog helps me a great deal in understanding the article and gives some extra insights!

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