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November 02, 2006

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Daniel Haszard

Zyprexa for Alzheimer's related agitation ~

My CC (chief complaint) against Eli Lilly's Zyprexa is it has a TEN TIMES greater incident of causing type two diabetes.

As regards giving it to someone who is terminally ill with late stage Alzheimer's related agitation and aggression i have less problem.

I think (and it's just my opinion) that these 'anti-psychotics' are ineffective for many mental illnesses all they do for most patients is make you sleep so that your aggression is 'turned off'.

For some who have hallucinations they are effective.They gave it to me for PTSD (post traumatic stress disorder) and it had the paradoxical effect of making me worst,because you can't give anti-aggression drugs to patients who are hyper vigilant from PTSD.
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Respectfully submitted,Daniel Haszard Bangor Maine zyprexa-victims.com

Deb Peterson

Hi Mona
Thanks for this post! My mother has been on Zyprexa for almost two years, and I was aware of some concern over prescribing it for AD sufferers. She was hallucinating when it was originally prescribed. She hasn't had any more hallucinations like the initial one, but I've noticed that she sometimes comments that she sees patterns in unexpected places. We have a large philodendron plant in the living room and she once told me she saw what looked like a face in the pattern of the leaves. I'm not sure if it's connected to her earlier hallucinations, or if it signals a change in her visual abilities. In any case, I have not advocated for stopping the Zyprexa despite my concerns. And there IS a lot to be said for its sedative properties at this stage. It's so complex, isn't it?

Patty Doherty

My father was given Risperadol. It had little to no effect on his hallucinations, but totally knocked him out. It was such a small dose that he took, we wondered how it could have such a huge effect on him. But it did.

He was constantly on the look out for "that guy". That guy was his reflection. He would first be nice to it, then be agitated with it and finally, he'd want to fight it. It was quite the complex maneuver to get him past a row of store windows, a mirror in a rest room, or a mirrored elevator. Oh the elevator was the worst. We solved the problem at home by painting over the mirrors, who knew we had so many?! and keeping a sheet over the car in the garage. The blinds were drawn at night and we basically lived like that for years. The amount of medication needed to stop the hallucinations would have put him to sleep for the entire day and night. Instead, we learned to work around it, and bizarre as it may sound to people who haven't experienced this, it became a "normal" part of our lives.

Ajlouny

The FDA has a tough line to walk to try and get medications to people that can receive benefit, but not so early as to miss major problems. When side effects occur only in 0.1% of the subjects, you need to have 10s of thousands of subjects to really see it become statistically significant from placebo. Yes, it is sad that this happens, but there is just no way to prove that drugs are conclusively safe before they are approved.

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