One of the test results I found in Dad’s records was for a mutation in a gene called MHTFR. His medical records say:
Methylenetetrahydrofolate reductase (MHTFR) FRET genotype analysis to identify the C677T polymorphism. Genotype result: A/A (Normal)
The U.S. National Library of Medicine has a Genetics Home Reference site written for consumers who want to know more about genetic conditions. Information on that site says mutations in this gene are associated with cardiovascular disease and elevated levels of an amino acid called homocysteine. Elevated levels of homocysteine in the blood are thought to increase the risk for cerebrovascular disease and Alzheimer’s disease.
Some researchers have suggested a possible association between a particular mutation of the MHTFR gene and Alzheimer’s disease or vascular dementia, but recent studies have not found any strong association, except in Japanese and Chinese populations.
Even if this genetic mutation were a problem, Dad didn’t have it. His homocysteine levels were also normal. None of his doctors ever mentioned this genetic test or homocysteine levels, so I guess they didn’t feel this was likely to be a factor in his dementia.